cost-effectiveness of methadone maintenance treatment in prevention of hiv among drug users in shiraz, south of iran

background the increase in high-risk injections and unsafe sexual behaviors has led to increased hiv infection prevalence among intravenous drug users (idus). the high costs of hiv/aids care and low financial resources necessitate an economic evaluation to make the best decision for the control of hiv/aids. objectives this study was conducted to determine the cost-effectiveness of methadone maintenance treatment (mmt) centers in hiv infection prevention among drug users. materials and methods in this interventional study, we included all the seven mmt centers and the drug users registered there (n = 694). we calculated all the costs imposed on the government, i.e. provider of case. mathematical models were used to estimate the number of hiv cases averted from high-risk behaviors. sensitivity analyses were performed to show the effects of uncertainty in parameters on the number of hiv cases averted and also incremental cost-effectiveness ratio (icer). results based on the averted models, the selected mmt centers could prevent 128 hiv cases during 1 year. the total cost was $ 547423 and that of hiv/aids care in the no intervention scenario was estimated $ 14171816. icer was $ 106382 per hiv case averted. the results of the sensitivity analysis indicated that mmt intervention was cost-effective even in the worst scenario and icer varied from $ 39149 to $ 290004 per hiv case averted. conclusions with regard to the high prevalence of drug injection among drug users and considering the high effectiveness and cost-effectiveness of mmt centers in preventing hiv infection, establishment of mmt centers in regional and national levels seems reasonable.